Of the 293 iMO–human genes (Table 3), 83 were found among our compiled set of 732 human AUD genes. Based on literature reviews, only 51 of these had been implicated in 1 or more aspects of AUD (Table 4). The remaining 32 genes were among the HuGe Navigator “alcoholism” genes, but had no experimentally supported connection to AUD and were ignored. Hereafter, the 51 genes in Table 4 are referred to as iMO–human-AUD genes because (i) their respective orthologs influence behavioral responses to alcohol in iMOs and (ii) they have been implicated in human AUD. As expected, ALK, AUTS2, GPC5, LMO1, and several SWI/SNF orthologs—genes previously described within single reports as modulators of alcohol behavior in iMOs and human AUD—were among the 51 iMO–human-AUD genes. Seven of the iMO–human-AUD genes were derived from studies in both flies and worms, while 23 and 21 were orthologs of genes identified exclusively in fly and worm studies (Table 4).
