Unfortunately, there is no consensus set of human AUD genes that can be used to determine which of the iMO–human genes (Table 3) have been implicated in human AUD. Thus, the 293 iMO–human genes were queried against a set of 732 human genes compiled from (i) several comprehensive reviews on the genetics of AUD (Edenberg and Foroud, 2013, 2014; Palmer et al., 2012; Rietschel and Treutlein, 2013; Schuckit, 2014) and (ii) genes in the HuGe Navigator (Yu et al., 2008) identified by the search terms “alcoholism.” A small number of these 732 human genes have established roles in AUD, whereas the remaining genes have been implicated in AUD by smaller scale studies, single studies only, etc. Although very few of the 732 genes were implicated by studies that observed formal statistical significance of association with AUD, we included all 732 genes in our analyses in an attempt to capture the broad landscape of genetic findings from studies in humans.
