We also tested the overall PGC2 PTSD PRS in the external MVP replication cohort, using REX as the target for predictions. PRS predictions were strongest at PT = 0.3 and highly significant (likelihood ratio test P = 5.4 × 10−62, Supplementary Fig. 27). Mean REX symptoms in MVP EUA participants was 8.48 (4.59 SD), and participants in the 5th quintile of genetic risk had significantly higher REX scores than subjects in the 1st quintile (beta = 0.58, P = 1.41 × 10−48; Fig. 2b).
