Analysis of shared heritability across common disorders of the brain17 and specific genetic correlations of psychiatric disorders with cognitive, anthropomorphic and behavioural measures10,18–20 has been facilitated greatly by the development of a centralized database of GWAS results including a web interface for LDSC (LD Hub21). We estimated pairwise genetic correlations (rg) between PTSD and 235 disorders/traits and found 21 significant correlations after conservative Bonferroni correction (Fig. 3, panel A and Supplementary Data 3). Genetic variation associated with PTSD was positively correlated with PRS from other psychiatric traits including depressive symptoms, schizophrenia and neuroticism, as well as epidemiologically comorbid traits such as insomnia, smoking behavior, asthma, hip-waist ratio and coronary artery disease. In contrast, negative rg with PTSD include subjective well-being, education, and a strong correlation with parents’ age at death (rg = −0.70). Significant positive correlations were also found for reproductive traits such as the number of children ever born, and, as previously reported for women22, PTSD was negatively correlated with age at first birth.
