BPD may be associated with an imbalance of excitatory and inhibitory neurotransmission in developing neurons. Interestingly, postmortem data on autopsied hippocampus indicate a decrease in GAD1 mRNA in BPD patients [11]. These data raise the question whether the increase in GAD1 mRNA in developing neurons differentiated from iPS cells is a compensatory response. Of note, Madison et al. [22] also found GAD1 to be differentially regulated between BPD and control CXCR4+ NPs.
