There is a strong association between the clonal mosaic anomalies detected in our study and hematological cancer. We estimate the risk of acquiring a hematological cancer diagnosis as 10-fold higher for subjects with mosaic anomalies. This association is strongly supported by finding that many of the mosaic anomalies are characteristic of those found in hematological cancers. Nevertheless, the event numbers analyzed here are small and additional studies are needed across a broader diversity of cohorts to establish the clinical significance of these findings.
