Notwithstanding the strong association with hematological cancer, we estimated that ~97% of subjects with clonal mosaic anomalies did not have a record of a hematological cancer prior to DNA sampling and the incidence rate is low (~ 14% over ten years in subjects who survive and are not lost to follow-up during this period). These results suggest that the clonal mosaicism observed in elderly subjects may be an asymptomatic condition with a predisposition to hematological cancer that is often not realized.
