In an attempt to replicate our genomics findings in an adequately-powered external study we used the large MVP cohort, including 146,660 EUA and 19,983 AFA participants assessed for re-experiencing symptoms (REX), a core feature of PTSD9. We first compared the genetic signals between PGC2 PTSD and MVP REX EUA and found a highly significant genetic correlation (rg = 0.80, SE = 0.096, P = 2.85 × 10−17). No evidence of replication was found for the six leading PTSD markers identified in PGC2 EUA and AFA GWAS for the MVP REX-specific symptoms (Supplementary Table 9). However, two of these markers were not directly genotyped and had to be assessed by proxy markers in only moderately high (~75%) LD, and sex-stratified analyses were not available for MVP.
