EEG studies are confronted with two major methodological problems. First is the management of the abundant artifacts, such as eye movement, eye blink and muscle activity, observed in young and behaviorally difficult to manage children. It has been well established that even EEGs that appear clean by visual inspection may contain significant artifacts [43,44]. Moreover, as shown in schizophrenia EEG research, certain artifacts may be group specific [45]. Second is capitalization upon chance, that is, application of statistical tests to too many variables and subsequent reports of chance findings in support of an experimental hypothesis [43,46]. Methods discussed below were designed to specifically address these two common problems.
