To better understand the improvement of PolyFun + SuSiE over SuSiE, we examined the 121 loci where PolyFun + SuSiE identified a fine-mapped common SNP (PIP>0.95) but SuSiE did not (PIP<0.5 for all SNPs within 1Mb) (Figure 3 and Supplementary Table 16). In each case, functional annotations prioritized one SNP out of several candidates, greatly improving fine-mapping resolution.
