AUBs were measured somewhat differently in the FTC sample. However, because this is the only cohort with data collected into older adulthood (up to age 67), it provides important additional information about the trajectory of genetic risk later in life. We therefore include data from four AUBs measured in this sample. Frequency of alcohol use (“How often do you drink alcohol?”) was measured for beer, wine and spirits separately and the maximum value across beverage types within wave was taken (Freq) and recoded into a pseudo-continuous count of days per month. gEtOH was a composite measure of grams of ethanol consumption per month, x ☐ log(x+1) transformed, as previously described (39). Heavy was a dichotomous indicator of whether participants drink “more than five bottles of beer or more than a bottle of wine or more than half a bottle of hard liquor” on the same occasion, at least once a month. Finally, PassOut was a pseudo-continuous measure of the number of days in the past year that participants passed out due to alcohol consumption. Measures were binned in 2-year age