Chunk #28 — 2. Inhibitors of the NF-κB activation pathway — 2.8. Other mechanisms of NF-κB inhibition — 2.8.3. Bacterial, fungal, and viral proteins

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Inhibiting NF-κB activation by small molecules as a therapeutic strategy.

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The YopJ protein, a Src homology 2 domain protein encoded by Yersinia pseudotuberculosis, inhibits NF-κB activation by preventing the phosphorylation and degradation of IκBα [161]. YopJ has also been shown to bind directly to IKKβ in vitro and in vivo [162]. The Salmonella typhimurium AvrA protein also inhibits NF-κB activation, although its mechanism of action may be different than that of the YopJ protein [163].