Gliotoxin produced by the fungus Aspergillus fumigatus has been reported to inhibit NF-κB activation by preventing IκB degradation [164]. Several other small molecules synthesized by microorganisms or designed derivatives of such compounds that have NF-κB-inhibiting potential include panepoxydone (from Lentinus crinitus) [165], 5,6 epoxycyclohexenone compounds (from Amycolatopsis), and cycloepoxydon [166]. Such compounds may affect distinct parts of the NF-κB pathway including DNA binding, nuclear translocation, and IκBα phosphorylation and degradation.
