Chunk #30 — 2. Inhibitors of the NF-κB activation pathway — 2.8. Other mechanisms of NF-κB inhibition — 2.8.4. Anti-inflammatory and immunosuppressive agents
Various anti-inflammatory agents including glucocorticoids, non-steroid anti-inflammatory drugs (NSAIDs), and immunosuppressants have been developed to block NF-κB activation. Glucocorticoids, which are commonly used as anti-inflammatory drugs, strongly inhibit NF-κB activation by mechanisms that are not completely understood but likely include inhibition of DNA binding, IKK activity and transactivation [167]. The glucocorticoids dexamethasone, prednisone and methylprednisolone have been reported to inhibit NF-κB activation. In addition, estrogen and selective estrogen receptor modulators (SERMs) such as raloxifene can act through the estrogen receptor to inhibit NF-κB activation [168, 169].
