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Chunk #7 — 1. Introduction/Background

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Gene expression changes in serotonin, GABA-A receptors, neuropeptides and ion channels in the dorsal raphe nucleus of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking.
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The links between the DRN and the reward centers of the brain, its role in anxiety, stress and depression, and the changes that occur during adolescence make it an important region in which to study the effects of heavy alcohol exposure, particularly during the vulnerable period of adolescence. This study examines the effects of binge drinking by adolescent P rats on the gene expression profile of the DRN.