Significant relationship with AUDIT and FTND were found in four rsFNCs as described in Table 3. No significant relationship with the other considered confounding factors was found in any of the four results displayed in Table 3. In smokers, the connectivity between L Angular and Precuneus RSNs increases with the FTND measure. No relationship with FTND was found for thalamus vs. putamen, which is the only other rsFNC with group difference between CTR and SMK groups. The rsFNC between Postcentral-3b and R Fusiform Gyrus/Lingual RSNs decreased as the AUDIT score increases for the DRN samples. This relationship coincides with the general hypo-connectivity found in alcohol consumers between sensorimotor and visual areas. Two rsFNCs were related to the interaction of FTND with AUDIT. The SMA-6 vs. R IOG and the L Fusiform/Lingual vs. Cuneus rsFNCs decreased as the interaction term increased.
