The rsFNC differences driven by drinking followed a similar pattern as those in the smoking and drinking category. The most prominent result is hypo-connectivity among SAL, PRE, SEN and VIS RSNs. A distinctive exception to the spread hypo-connectivity pattern is the increased connectivity in the DRN group compared to the CTR group between the reward system, represented by the putamen, and areas of visual processing characterized by the Lingual/Vermis RSN. Only two rsFNC results were found to be driven by smoking including a hypo-connectivity between thalamus and putamen plus a hyperconnectivity between precuneus and left angular gyrus.
