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Chunk #20 — 4. Discussion

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Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex.
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The involvement of ZNF804A in SZ and BD was evaluated by a combined approach: i) we genotyped the rs1344706 and rs12476147 SNPs in an independent sample of 428 SZ, 385 BD and 578 controls from the demographically well characterized population of the CVCR; and ii) we analyzed the rs12476147 ASE in the DLPFC of 46 heterozygous postmortem brains.