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Chunk #52 — 4. Discussion

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Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice.
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Alcohol is not only a pharmacological substance but also a nutrient with energy content (Forsander, 1998; Kiefer, 1995). However, in agreement with earlier findings (Cross-Mellor et al., 1999), pretreatment with LPS did not change the intake of highly caloric solutions of sucrose. Therefore, the increased alcohol intake could not be a result of changes of alcohol palatability.