It is thought that the avoidance of more concentrated ethanol solutions can be related to increased bitterness (Kampov-Polevoy et al., 1990; Goodwin et al., 2000). Although increased consumption of bitter solutions of quinine found in B6 male mice after LPS are consistent with the increased alcohol intake, other changes in quinine consumption were not correlated with changes in alcohol intake. For example, males and females showed similar differences in alcohol drinking, but females did not show any differences in quinine intake after LPS treatment.
