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Chunk #31 — 3. Results — 3.3. Follow-Up Analyses — 3.3.3. Cannabis Use Disorders as Potential Moderators for Comorbid Alcohol and Substance Use and Mental Disorders

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A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset.
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The first model (Figure 1) revealed a significant direct and indirect effect of bipolar disorder on a number of other comorbid substance use disorders. The number of Cannabis use disorder criteria met had a significant moderating effect (variance explained 3.7%). In comparison, the direct and indirect effects of bipolar illness and the number of Cannabis disorder criteria on the prevalence of other comorbid psychiatric disorders (model 2, Figure 2) is low (variance explained 4.8%).