Chunk #33 — 3. Discussion

Source

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.

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In conclusion, CYP2A5 protect against the development of alcoholic fatty liver disease, and FGF21 acts as a downstream molecule of PPARα signaling pathway to regulate liver lipid metabolism and contribute to the CYP2A5 protective effects on alcoholic fatty liver disease.