Chronic ethanol-induced fatty liver is more pronounced in Cyp2a5−/− mice. (A) H&E staining. (B) Steatosis quantification (N=5). (C) Liver and serum TG (N=5). (D) Expression of CYP2A5, PI3K, AKT, and IRS by Western blotting analyses. (E) Quantitation of Western blots (N=4). *P<0.05, compared to Cyp2a5+/+ Control Group; # P<0.05, compared to Cyp2a5−/− Control Group; & P<0.05, compared with Cyp2a5+/+ Ethanol group. Cont, Control; EtOH, Ethanol.
