Chunk #23 — 3. RESULTS — 3.1. The G (Asp) allele of rs1799971 shows a modest protective effect on general substance dependence

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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

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To further confirm robustness, we examined the effect of redefining general dependence using alternative definitions for nicotine dependence, namely the Fagerström Test for Nicotine Dependence (FTND) (case ≥ 4, control ≤ 1; 13 studies, N = 8,481) or DSM-IV nicotine dependence (14 studies, N = 11,711), in place of our CPD-based heavy/light phenotype (20 studies, N = 16,908). Analyses of these smaller samples gave similar protective odds ratios for general dependence, though results were not statistically significant: OR = 0.91, 95% C.I. (0.81–1.02) for FTND and OR = 0.94, 95% C.I. (0.85–1.03) for DSM-IV nicotine dependence.