Chunk #24 — 3. RESULTS — 3.2. For each substance-specific dependence, the G allele of rs1799971 is similarly protective but non-significant

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Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.

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In our primary test of rs1799971 genotype as the dependent variable on the 9 datasets that had assessed all five substance dependence diagnoses and exposures, we obtained odds ratios that ranged from 0.89 (nicotine dependence) to 0.92 (cocaine dependence). The odds ratio for each specific substance showed the same protective direction as that for general substance dependence, though none was statistically significant in these smaller samples (Table 4). Also, odds ratios for specific substances did not differ significantly from each other (Table S2), suggesting consistency across substances.