The rGs between the PTSD phenotypes and alcohol consumption phenotypes (i.e. DPW, AUDIT-C, AUDIT-T) are negative and varying in degree from small to large for those of AA (AUDIT-C and PTSD Re-Exp rG: 0.145, NS; AUDIT-C and PTSD rG: 0.699, unadjusted p < 0.05), in contrast to the positive and mostly moderate rGs of PTSD and AUD phenotypes. For those of EA, the genetic correlations between PTSD and PTSD Re-Exp and DPW across samples were negative, small, and non-significant ( p > 0.05), with the exception of DPW (UKB) genetic correlations with PTSD Re-Exp, however it did not pass FDR adjustment. The rGs between PTSD phenotypes with AUDIT-C and -T were low to moderate. However, the rGs with AUDIT-C across samples were moderate [rG: −0.417 to −0.225; with the exception of AUDIT-C (UKB) – PTSD Re-exp rGs: −0.188], significant and passed FDR correction. Whereas the genetic correlation between AUDIT-T (UKB) and PTSD Re-exp was the only significant association, albeit small, among all the AUDIT-T analyses for EA. The highest rG among PTSD and alcohol consumption-related phenotypes was that of AUDIT-C (MVP) with PTSD (rG: −0.417, FDR adj. p = 2.59 × 10−7).
