Participants were recruited through advertisements in local media, on Internet Web sites, by flyers, and by word-of-mouth referrals. In-person screening included administration of the Alcohol Quantity-Frequency52 and Timeline Follow-Back53,54 interviews to assess alcohol drinking patterns during the past 3 to 6 months. In addition, the screening portion included self-report questionnaires, including the Alcohol Use Disorders Identification Test,55,56 the Beck Depression Inventory,57 and the Spielberger State-Trait Anxiety Inventory.58 Participants took part in a modified Structured Clinical Interview for DSM-IV Axis 1 Disorders–Patient Edition59 that included the screening module and specific modules for mood episodes and substance use disorders, as well as a brief physical examination and urine and blood testing. Exclusion criteria were history of major Axis I psychiatric conditions, including alcohol or substance dependence (excluding nicotine), abnormal blood chemistry or hepatic panel results (≥2 SD above the mean), positive breathalyzer or urine toxicology screen (cocaine, opiates, benzodiazepines, amphetamines, barbiturates, and phencyclidine), or positive pregnancy test. Recreational marijuana use was allowed, provided it was used no more than 3 times weekly. Participants also completed a 2-generational FH tree for alcohol use
