In conclusion, the epigenetic landscape represented by DNA methylation in the human brain shows dramatic variation across development. Genetic loci implicated in risk for schizophrenia and other CNS disorders are enriched for loci expressing these shifting epigenetic states, particularly those that change from the transition from prenatal to postnatal life. While these observations do not identify specific molecular mechanisms of the clinical associations, they suggest that there is an important epigenetic intermediate between sequence of risk and cell biology of risk.
