We also explored the relationship of genetic risk loci associated with Alzheimer’s disease, Parkinson’s disease and T2D. None of these disorders showed the enrichment of CpGs hypermethylated during fetal life associated with risk loci for schizophrenia, though the GWAS catalog of risk associated variants is smaller in these cases. Interesting, there was a small enrichment with CpGs showing significant hypermethylation in postnatal life and risk loci for T2D. While the interpretation of this finding is highly speculative, it might reflect adult lifestyle influences on risk for T2D.
