The third major research question explored was whether the subjectively experienced effects of alcohol and/or blood ethanol concentrations (BEC’s) were associated with alcohol-induced changes in PLI or PDLI to the infrequent/target tones in the human participants, using Spearman and Pearson correlations. The total score on the Subjective High Assessment Scale (SHAS) at 60 minutes following ethanol ingestion was found to be significantly associated with PLI changes in the beta frequency range in FZ using both the Pearson and (r=.337, p<0.04) Spearman (r=.412, p<0.01) correlations (see figure 6). Administration of 0.56 g/kg ethanol produced a mean ± SD (g/dL) BEC of 0.077 ± 0.02 at 60 min after beverage ingestion. BEC’s were found to be significantly associated with changes in PLI in the alpha frequency range in PZ using both the Pearson (r=-.327, p<0.045) and Spearman (r=-.325, p<0.046) correlation (see figure 6). No significant associations were found between PDLI values and SHAS and BEC measures. Blood ethanol concentrations were not available for the rats; however, our previously published pharmacokinetic data suggest that BECs for a 1.5 G/kg dose at 60 minutes following the injection yields a BEC of .1-.15 G/dL.
