Chunk #50 — ONLINE METHODS — Integration of GWA findings to tissue and cellular gene expression

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

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We conducted eQTL look-ups of the most associated SNPs in each region and report GWA SNPs in LD (r2 > 0.8) with the top eQTLs in the following data sets: eQTLGen Consortium (lllumina arrays in whole blood N=14,115, in preparation), BIOS (RNA-seq in whole blood (N=2,116),94 NESDA/NTR (Affymetrix arrays in whole blood, N=4,896),95 GEUVADIS (RNA-seq in LCL (N=465),96 Rosmap (RNA seq in cortex, N= 494)97, GTEx (RNA-seq in 44 tissues, N>70)43, and Common Mind Consortium (CMC, prefrontal cortex, Sage Synapse accession syn5650509, N=467)51.