Chunk #49 — ONLINE METHODS — Integration of GWA findings to tissue and cellular gene expression

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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

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Lists of genes specifically expressed in neurons, astrocytes, and oligodendrocytes were obtained from Cahoy et al.45 As these experiment were done in mice, genes were mapped to human orthologous genes using ENSEMBL. The coordinates for these genes were extended by a 100kb window and tested using LD score regression as for the GTEx tissue specific genes.