Table 2 includes the top five genes with the lowest P-values obtained in the gene-based analysis along with their functions (according to GO annotations).Table 2Top five genes showing the strongest association with age at onset of cannabis useGene name (Gene ID)ChrStart positionNumber of SNPs assigned to geneKey SNPs position (rs number)Gene featureKey SNPs P-value (lambda adjusted)Gene P-valueMolecular function according to gene ontology annotationGem (nuclear organelle) associated protein 5 (GEMIN5)51542669753154289310 (rs148816132)Intronic1.4 × 10−5 4.7 × 10−4 Protein binding; snRNA binding154272889 (rs816735)Intronic0.038–Uncharacterized LOC101927911 (LOC101927911)17286554092871545 (rs4790396)Intronic1.6 × 10−4 4.7 × 10−4 –Metallothionein 4 (MT4)16565989601356598707 (rs141262031)Upstream1.9 × 10−5 5.2 × 10−4 Copper ion binding; zinc ion binding.56605477 (rs4784686)Downstream0.001–56596812 (rs71387120)Upstream0.003–Kinesin family member 4B (KIF4B)51543932591154401490 (rs115299630)Downstream3.9 × 10−5 5.3 × 10−4 Nucleotide binding; DNA binding; microtubule motor activity; ATP binding; microtubule binding;Peptidylprolyl isomerase G (cyclophilin G) (PPIG)217044084953170439011 (rs118138006)Upstream3.5 × 10−5 5.8 × 10−4 Peptidyl-prolyl cis–trans isomerase activity; isomerase activity;170444201 (rs78740435)Intronic5.7 × 10−5 –170437115 (rs12618592)Upstream1 × 10−4 –170497179 (rs3731675)Downstream1.4 × 10−4 –170480402 (rs12612841)Intronic6.5 × 10−4 –170471270 (rs115697204)Intronic6.5 × 10−4 –170466028 (rs75173877)Intronic6.7 × 10−4 –170461257 (rs7421113)Intronic0.001–170477394 (rs75968631)Intronic0.001–
