In our exploratory gene-based analysis none of the genes reached the genomewide significance threshold of α = 4.3 × 10−7. The genes showing the strongest association with our phenotype were Gem (nuclear organelle) associated protein 5 (GEMIN5) on chromosome 5 (P = 4.7 × 10−4) and the uncharacterized LOC101927911 on chromosome 17 (P = 4.7 × 10−4), followed by the Metallothionein 4 (MT4) on chromosome 16 (P = 5.2 × 10−4). The SNP with the strongest association signal—the rs142324060 (lambda-corrected P = 7.6 × 10−8) was not assigned to a gene in the GATES analysis.
