Recently, a role for eCB signaling at thalamic inputs to the LA has also been demonstrated (Shin et al., 2010). In this study, LFS of thalamic inputs to the LA combined with post-synaptic depolarization resulted in LTP that is expressed post-synaptically. This post-LTP requires post-synaptic calcium and CB1 activation to suppress a form of kainate-mediated presynaptic LTP. These authors conclude that combined LFS and post-synaptic depolarization releases eCBs that counteract LFS-induced presynaptic LTP, resulting in an exclusive post-synaptic LTP. These data suggest a hierarchical order of pre- and post-synaptic LTP at thalamo-LA synapses that is regulated by eCB signaling (Shin et al., 2010).
