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Chunk #2 — Introduction

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case, Anders and Marty wanted to use the fact that pyramidal neurons in the cortex are thought to be the source of the vast majority of the EEG/MEG signal. Cortical surface models would therefore give them access to the location of the pyramidal neurons. Further, because the processes of these neurons are typically oriented perpendicular to the cortical surface, the surface models would also provide orientation constraints on the underlying dipoles. Thus, the surface models allowed a strong and neurobiologically plausible set of constraints to be applied to the inverse problem, resulting in a linear inversion that minimized the L2 norm of the solution and provided some of the first spatiotemporal movies of estimated human brain activity (Dale, 1994).