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Chunk #1 — Introduction

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FreeSurfer.
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It is this last functionality—the construction of cortical surface models—that was the motivation for the development of the software that would eventually become FreeSurfer. The surface reconstruction code traces its roots to Anders Dale's Ph.D. dissertation work with Marty Sereno in the early 1990s (Dale, 1994), in which the surface models were used to solve the EEG/MEG inverse problem (Dale, 1994; Dale et al., 2000). The EEG/MEG inverse problem is that one records electromagnetic signals outside the skull with electrodes (for EEG) or magnetometers/gradiometers (for MEG), but one wishes to recover the set of currents inside the brain that gave rise to the measured signals. This is a fundamentally ill-posed problem in that an infinite distribution of source currents can give rise to the same measurements. Thus one must apply some constraints in order to obtain a solution. In this case, Anders and Marty wanted to use the fact that pyramidal neurons in the cortex are thought to be the source of the vast majority of the EEG/MEG signal. Cortical surface models would therefore give them access to the location