Of course, the function of any neurotransmitter, including 5HT, is complicated and contextual. For example, different 5HT transporters have been shown to have different and sometimes opposing affects on risky behaviors. It appears that reduction in 5HT available for the very common 5HT2c receptor sites and for 5HT1a receptor sites tends to be associated with the classic increased emotionality/increased risky behavior effect, whereas reduced 5HT for the less common 5HT2a receptor sites has the opposite effect (Carli, Baviera, Invernizzi, & Balducci, 2006). Winstanley et al. (2004) found that 5HT2A and 5HT2C receptors differentially affect behavior; depletion of 5HT in the 5HT2A receptor results in higher levels of risky behavior, whereas depletion of 5HT at the 5HT2C receptor results in lower levels of risky behavior.
