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Chunk #21 — Results — GABRA2 variants and Lifetime Alcohol Related Problems (LAPS)

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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
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included in the final model. However, as expected LAPS scores were significantly higher in the AUD group (12.5 ± 2.1) compared to the non AUD subjects (8.9 ± 1.9) (p < 0.00001). Figure 1 depicts the location of the four associated SNPs with LAPS, highlighting the strength of the association around SNP rs279827. Similar results were obtained In the Caucasian sample when we checked for possible stratification. Homozygotes for the minor haplotype (CCGG/CCGG) showed significantly higher scores of LAPS (p = 0.024) (Table 3), but the haplotype was not a better variable than the most significant SNP alone.