Of the three LAPS components (age of first drunkenness, number of different alcohol related difficulties at any time and index of life course duration of all drinking related problems from onset to present, corrected for risk exposure), the association with GABRA2 SNPs was driven mainly by number of alcohol related difficulties (p < 0.04) and index of life course duration of all drinking related problems (p < 0.05), and not by age of first drunkenness.
