rs17641078 Additive4.73E-0691046959In coding exon of DMRT2Encodes doublesex and mab-3 related transcription factor 2, a potential regulator of sex differentiation. Expressed in multiple tissues, including brain. Falls into/close to suggestive linkage regions for autism (Allen-Brady et al. 2008; Szatmari et al. 2007b) and close to suggestive linkage region for nicotine dependence (Li et al. 2008)Site known for CNVs rs17641078 Dominant8.44E-0691046959 rs708188 Recessive2.17E-061228111983See above rs522958 Recessive7.59E-071228119834See abovers363512Dominant3.89E-062129972688In intron of GRIK1Encodes glutamate receptor, ionotropic, kainate 1. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Earlier association studies suggest involvement of the gene in epilepsy en Parkinson’s disease (Lasky-Su et al. 2008b). Gene is also found in GWAS in bipolar disorder with P values at 10−4 (Wellcome Trust Case Control Consortium 2007)FBAT-PC inattentive symptoms rs552655 Dominantn.a.#613478466Intron of GFOD1Encodes glucose-fructose oxidoreductase domain containing 1 a gene expressed in brain and other tissues. The protein is predicted to be involved in electron transport and metabolic processes. Finding lies within linkage region for schizophrenia from meta-analysis (Lewis et al. 2003)
