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Chunk #30 — Review

Source
Genome-wide association studies in ADHD.
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of unknown function. Expressed in brain and other tissuesWithin linkage region for ADHD as identified in meta-analysis (Zhou et al. 2008c)rs260461Dominant8.38E-061963462695Within intron or 3’UTR of ZNF544Encodes zinc finger protein 544, a zinc-regulated transcription factor expressed in brain and many other tissues rs130575 Additive4.67E-062233189793IntergenicPresent in or near (suggestive) linkage regions for schizophrenia reported in meta-analysis (Lewis et al. 2003), for nicotine dependence (Saccone et al. 2007; Kelsoe et al. 2001) rs130575 Dominant6.20E-062233189793FBAT-PC hyperactive-impulsive symptoms rs1018040 Additive8.20E-061216772437See abovers6719977Additive1.67E-06242839307Within 2 kb downstream of MTA3Encodes metastasis associated 1 family, member 3, a component of the nucleosome-remodeling and histone-deacetylase multiprotein complex (NuRD). MTA3 plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and the regulation of E-cadherin levels. Expressed in multiple tissues, including brain, especially cerebellumClose to rs930421 associated with FBAT-PC all symptoms and rs10865184 showing association with ADHD symptom count in interaction with maternal criticism rs6808138 Additive5.38E-063162875270IntergenicSite known for CNVs rs6808138 Dominant8.21E-063162875270rs41441749Dominant1.49E-06618899702Intergenic rs17641078 Additive4.73E-0691046959In coding exon of DMRT2Encodes doublesex and mab-3 related transcription factor 2, a potential regulator of sex differentiation. Expressed in multiple tissues, including brain. Falls into/close to suggestive linkage regions for autism (Allen-Brady et al. 2008; Szatmari et al.