cerebellum) and other tissues. Function unknown. Within schizophrenia linkage region observed in meta-analysis (Lewis et al. 2003)rs1350666Additive8.30E-06475443454Within 15 kb upstream of EREGEncodes epiregulin, a member of the epidermal growth factor family, which can bind to the EGF receptor and may be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis rs708188 Recessive7.21E-061228111983IntergenicWithin 5 kb of genome-wide significant association for type 2 diabetes (Zeggini et al. 2007) rs522958 Recessive1.03E-061228119834Intergenicrs1514928Additive3.05E-061461748056Within 110 kb downstream of SYT16Encodes synaptotagmin XVI, which may be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent and expressed in brainSite known for CNVsrs8047014Additive3.52E-061667692550Within 5 kb upstream of HAS3, within 20 kb downstream of TMCO7HAS3 encodes hyaluronan synthase 3 isoform a, a protein involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. Expressed in brain and other tissuesTMCO7 encodes transmembrane and coiled-coil domains 7, a protein of unknown function. Expressed in brain and other tissuesWithin linkage region for ADHD as identified in meta-analysis (Zhou et al. 2008c)rs260461Dominant8.38E-061963462695Within intron or 3’UTR of ZNF544Encodes zinc finger protein 544, a zinc-regulated transcription factor expressed in brain and many other
