Based on the same motif enrichment method mentioned above, we computed the motif enrichment in the tissue-specific DGF regions in each library. The tissue-specific DGF regions were identified by selecting the DGF region occurring no more than 20 DGF libraries among 42 DGF libraries. To generate Extended Data 9b, we standardized the motif enrichment in each library into z-scores for each motif (row) and color each DGF library (column) based on their tissue type.
