Table 3 addresses Hypothesis 5 (more intense alcohol and drug use and problems will be observed when AUDs and SUDs are seen in the same person). Here planned comparisons were used because some items were only relevant to groups with AUDs (e.g., age of onset of the AUD) and some were only appropriate for probands with SUDs. Beginning with demography, the only overall significant difference across the three groups at age 50 was the higher proportion of individuals in Group 3 (AUD only) who had ever been married, a finding that reflected higher proportions in Group 3 versus the comorbid diagnosis Group 1. The course of alcohol-related items for the two AUD groups (1 and 3) indicated that members of the combined diagnosis Group 1 endorsed more AUD items, an earlier AUD onset, a higher risk for alcohol-induced mood disorders, and a greater proportion who received formal AUD treatment or who attended AA meetings compared to Group 3. The drug-related items for the two SUD groups (1 and 2) indicated that members of Group 1 were more likely to use