that this seemingly paradoxical effect could be an artifact of low power: by definition very few participants would score either very high or very low on the AGRS scale (ie, this reflects the need to multiply the minor allele frequencies of each variant together to determine the proportion of the sample that will score in the highest AGRS category, with the result that the distribution for AGRS scores in a population will necessarily be leptokurtic). Thus, the veracity of this finding should be interpreted with caution, pending future replication.
