The tendency for both dependence level and AGRS to decrease time to relapse is consistent with the predicted directions (ie, higher dependence and higher genetic risk being associated with poorer treatment outcome). The interaction term suggests a slightly protective effect of genetic risk at high levels of dependence and may suggest that the platform treatment of counseling and nicotine patch that bupropion was added to in this trial may be optimized for those highly dependent individuals who carry high levels of dopaminergic genetic risk (conversely those participants who become highly dependent through etiological pathways not indexed by this dopaminergic AGRS may require a different treatment approach than this standard of care). This is more difficult to explain and may not be worthy of interpretation as the confidence interval for this effect was very close to including 1. We also note that this seemingly paradoxical effect could be an artifact of low power: by definition very few participants would score either very high or very low on the AGRS scale (ie, this reflects the need to multiply the minor allele frequencies
