As described previously, 18 GWAS of three phenotypes (adventurousness, 22 risk taking, 22 and UPPS‐P sensation seeking 21 ) conducted using primarily 23andMe, Inc., and UK Biobank (UKB) samples were specified as indicators of a sensation seeking genomic factor. Three GWAS were specified as indicators of an alcohol consumption genomic factor: (1) a ‘drinks per week’ GWAS meta‐analysis using data from 23andMe (N = 403,939) and the GWAS and Sequencing Consortium of Alcohol and Nicotine use (GSCAN; N = 537,341) 23 ; (2) an AUDIT‐C GWAS meta‐analysis using data from UKB (N = 121,604) 24 and Million Veteran Program (MVP) cohorts (N = 200,680) 25 ; and (3) an existing GWAS meta‐analysis of grams of alcohol consumed per day using UKB, the Alcohol Genome‐Wide (AlcGen) Consortium, and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus (CHARGE+) Consortium. 26 For AUD, a GWAS meta‐analysis was conducted using summary statistics for AUD/alcohol dependence from the Psychiatric Genomics Consortium (PGC), 27 the FinnGen Research Project Release 6 (FinnGenR6), 29 and MVP. 28
