Chunk #23 — MATERIALS AND METHODS — Statistical model — Joint inference on multiple samples

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QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.

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To allow for joint inference we place a Dirichlet prior on the transition matrix at each SNP, centred on the expected values given by Equation (2), and with precision K, 13 14 where vi, j, t = Kρ and ρ is given by Equation (2).