Chunk #22 — MATERIALS AND METHODS — Statistical model — Joint inference on multiple samples

Source

QuantiSNP: an Objective Bayes Hidden-Markov Model to detect and accurately map copy number variation using SNP genotyping data.

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We can extend QuantiSNP to analyse multiple samples, either the same individual assayed several times or single samples from multiple individuals, and use the data jointly to update our transition matrix. If the regions of CNVs are common across samples, joint inference allows for borrowing of strength and improved resolution to detect CNV boundaries.